Ewa Pajor and Salma Paralluelo both scored twice as Barcelona outclassed Lyon to be crowned European champions for the fourth time in their history.
Crystal Palace boss Oliver Glasner is "confident" the Eagles will win their appeal at the Court of Arbitration for Sport to play in the Europa League.
Bath secured a 37-12 Challenge Cup final victory over Lyon in Cardiff on Friday, but only after flanker Sam Underhill avoided a first-half red card.
Henry Slade held his nerve as Exeter launched their Champions Cup campaign with a stunning 19-18 victory over Toulon.
Former Chelsea and Brighton manager Graham Potter has declined the opportunity to take charge at Lyon.
La Rochelle broke Ulster hearts in the very final play to book a last-16 spot, while Ospreys, Saracens, Sharks and Bulls won too.
Leicester Tigers claimed a second Champions Cup win from as many rounds, beating Clermont, while Saracens dug deep to win at Lyon.
Lyon won their first major honour for 89 years as they claimed a thoroughly deserved 30-12 Challenge Cup final victory over Toulon.
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